This study examined the economic analysis of yoghurt marketing in Akure Metropolis, Ondo State, Nigeria. The study was motivated by the increasing demand for yoghurt as a nutritious dairy product and the need to understand the profitability and marketing challenges associated with a highly perishable commodity that requires efficient storage and distribution systems. Specifically, the study examined the cost and returns of yoghurt marketing operations, determined the factors influencing the profitability of yoghurt marketing, and identified the problems associated with yoghurt marketing in the study area. A two-stage sampling technique was used to select 80 respondents. Data were analysed using descriptive statistics, gross margin analysis, market margin, benefit-cost ratio, and multiple linear regression. Results showed that yoghurt marketing was profitable, with an average total revenue of ₦1,566.76 per litre, total variable cost of ₦1,144.60, and gross margin of ₦422.16. The benefit-cost ratio was 1.37, and the market margin was ₦663.21. Regression analysis revealed that educational level (p < 0.10), storage cost (p < 0.01), and purchase price (p < 0.01) significantly influenced profitability. Major constraints were poor transportation facilities (= 2.49) and low demand during the rainy season (= 2.29). The findings highlight the importance of storage and distribution efficiency in yoghurt marketing, which reflects the unique challenges associated with the marketing of perishable dairy products. The study concludes that yoghurt marketing is a viable and profitable enterprise in Akure Metropolis. It recommends improved access to affordable credit, investment in transportation and cold-storage infrastructure, and capacity-building programmes to enhance marketers’ efficiency and profitability.